Looking for a savory and comforting dish? Try our Cattle Drive Casserole recipe! Packed with ground beef, diced tomatoes, green chiles, and a creamy topping, it’s a flavorful delight for any mealtime. Perfect for busy weeknights or family gatherings.

Ingredients
- 1 1/2 pounds ground beef
- 1 (10 oz.) can fire-roasted diced tomatoes with green chiles
- 1 (4 oz.) can diced green chiles
- 1 (1.25 oz.) packet taco seasoning
- 2 1/2 cups biscuit mix
- 1 3/4 cups sharp cheddar cheese, shredded, divided
- 1 red bell pepper, diced
- 1/2 yellow onion, diced
- 1 cup water
- 1/2 cup sour cream
- 1/2 cup mayonnaise
- 1 teaspoon garlic powder
- Kosher salt and freshly ground black pepper, to taste
Preparation Steps
- Preheat Your Oven
Preheat your oven to 350º F and lightly grease a 9×13-inch baking pan with non-stick spray. - Cook the Beef and Veggies
In a large skillet over medium-high heat, combine the ground beef, diced red bell pepper, and chopped yellow onion. Cook until the beef is browned and the vegetables are softened. Drain any excess grease and set aside. - Season the Beef
Stir in the taco seasoning packet, adjusting with salt and pepper to taste. Ensure the seasoning is evenly distributed throughout the beef mixture. - Prepare the Creamy Topping
In a medium bowl, whisk together the sour cream, mayonnaise, 1 cup of the shredded cheddar cheese, diced green chiles, and garlic powder until smooth and well combined. - Make the Biscuit Base
In a separate bowl, mix the biscuit mix with 1 cup of water. Add a bit more water if needed to achieve a soft dough consistency. Press this dough into the bottom of the greased baking dish. - Pre-Bake the Biscuit Layer
Place the baking dish in the preheated oven and bake for 5-7 minutes, or until the biscuit layer is lightly golden. Remove from the oven. - Assemble the Casserole
Spread the seasoned beef mixture evenly over the pre-baked biscuit layer. Next, layer the fire-roasted diced tomatoes with green chiles on top of the beef mixture. - Add the Creamy Topping
Spoon the sour cream mixture over the tomatoes, spreading it out evenly. Sprinkle the remaining 3/4 cup of shredded cheddar cheese over the top. - Bake the Casserole
Return the baking dish to the oven and bake for 30 minutes, or until the casserole is warmed through and the cheese is melted and bubbly. - Serve and Enjoy
Remove from the oven and let the casserole cool slightly before serving. Enjoy this comforting, cheesy, and flavorful dish with your family and friends.
Why You’ll Love This Recipe
The Cattle Drive Casserole is the perfect blend of savory ground beef, vibrant vegetables, and a creamy, cheesy topping. It’s a versatile dish that can be customized to your liking – feel free to add your favorite toppings or mix-ins to make it your own. This casserole is also a great make-ahead meal, perfect for busy weeknights or family gatherings. Plus, it’s a crowd-pleaser that even the pickiest eaters will love.
FAQs
1. Can I use ground turkey instead of ground beef?
Yes, ground turkey can be a great substitute for a lighter version of this casserole.
2. Can I make this casserole ahead of time?
Absolutely. You can assemble the casserole a day in advance and bake it when you’re ready to serve.
3. What other vegetables can I add to this casserole?
Feel free to add vegetables like corn, black beans, or diced zucchini for extra flavor and nutrition.
4. Can I freeze the leftovers?
Yes, this casserole freezes well. Just be sure to let it cool completely before transferring it to an airtight container.
5. How can I make this dish spicier?
To add some heat, you can include diced jalapeños or extra green chiles, or use a spicy taco seasoning mix.
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